Original microfluidic device “iLiNP”

Microfluidic device “iLiNP” for lipid (polymer) nanoparticles manufacturing
The iLiNP (innovative Lipid Nanoparticles Production device) is the original microfluidic device suitable for manufacturing various kinds of lipid (or polymer) nanoparticles continuously from a lipid (or polymer) solution. The iLiNP consists of some inlets, outlet(s) and the channel having a lot of baffles.

 

Table of contents (Click to jump to each chapter)

  1. Mechanism of the nanoparticles formation in the iLiNP
  2. Advantage of the iLiNP
  3. Applications
  4. Pending patents

 

1. Mechanism of the nanoparticles formation in the iLiNP

In the microfluidic channel, the lipids/alcohol solution is diluted by water. When the alcohol concentration becomes lower, the lipid molecules no longer dissolve solely in the solution and start formation of Disk-like structure (DLS) by self-assembly.

If the dilution is slow, the DLS can grow until they reach their thermodynamically stable size, forming large-sized particles.
If the dilution occurs rapidly, the DLS cannot grow enough to form large-sized particles.

The channel structure and the flow rates determine the dilution speed of the lipid/alcohol solution.

By using the iLiNP and Lilac’s knowhow, you can easily obtain the particles of desired size (20-500 nm dia.).

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2. Advantage of the iLiNP

(1) Comparison between the batch process and the iLiNP
The iLiNP is a next-generation device having more advantages than the conventional batch process.

〇Easy to control the particle size.
〇Highly reproducible.
〇a few steps.

〇Easy to scale-up.

(2) Comparison among the other microfluidic devices
The iLiNP is the best microfluidic devices that overcomes the weaknesses that the other microfluidic devices have. 

〇Easy to control the particle size.
〇Highly reproducible.
〇No clogging.

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3. Applications

The iLiNP will be applicable in the manufacturing of not only the pharmaceuticals but also the clinical test kit, cosmetics, dietary supplement, chemical additives, research reagent etc.

We welcome your ideas regarding new application of the iLiNP.

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4. Pending patents
According to the PCT international search report, all the patent application will be patentable.

  1. Flow channel structure and lipid particle or micelle formation method using same.
    Application No. : PCT/JP2018/015550 -> JP, US, EP, CN, CA

                             107112803 (Taiwan)
    Applicants : NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Filing Date : Apr 13, 2018 (Priority date : Apr 13, 2017)
    License : Exclusive license granted to Lilac pharma Inc.
  1. Production method of particle containing solution
    Application No. : PCT/JP2019/043420

    Applicants : NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Filing Date : Nov 6, 2019 (Priority date : Nov 9, 2018)
    License : Exclusive license granted to Lilac pharma Inc.
  1. 3D-channel structure and nanoparticle formation method using same.
    Application No. : PCT/JP2019/039347

    Applicants : NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Filing Date : Oct 4, 2019 (Priority date : Oct 4, 2019)
    License : Exclusive license granted to Lilac pharma Inc.

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